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KMID : 0351619700110010229
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Kyungpook Medical Journal
1970 Volume.11 No. 1 p.229 ~ p.239
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Reactivity of Immunologically Competent Cells Toward Antigenic and Nonantigenic Stimulation in Immune Reaction
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Abstract
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The experiment was carried out to evaluate the role of lymph node in mediating irmm~nological reaction.
Various substances, antigenic or nonantigenic, were injected into the dorsal foot pad in rabbit subcutaneously and draining´ popliteal ]ymphno-.des were examined morphologically 3, 7, 10, 15, 20 and 30 days after injection of stimulants.
The conclusions obtained were as followings:
1. The lymphocytes are found not only to show a strong proliferative response to ~intigenic stimulation but also to exhibit a relatively active proliferative response to Freund´s incomplete adjuvant, a substance which its nonantigenic and only enhances antibody producion.
2. In immunological reaction produced by antigenic substances with adjuvant, biphasic responses of reactivity of Iymph node are distinct. The specific cellular proliferation, chiefly of large pyroninophilic cells, which is supposed to produce ultimate antibody formation, was followed by initial nonspecific proliferation of lymphocytes.
3. According to the clonal selection theory of Burnet, it is quite correct assuming that lymphocytes are supposed to respond only toward the antigenic stimulation during an immune response.
However, on the basis of present results, the proliferation of immunologically competent cells in immune response can divide into two distinct phases of nonspecific and specific ones, and the capacity of adjuvant to enhance antibody formation is supposed to stimulate the nonspecific phase of immune cellular proliferation.
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KEYWORD
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